835 research outputs found
Two component Bose-Hubbard model with higher angular momentum states
We study a Bose-Hubbard Hamiltonian of ultracold two component gas of spinor
Chromium atoms. Dipolar interactions of magnetic moments while tuned resonantly
by ultralow magnetic field can lead to spin flipping. Due to approximate axial
symmetry of individual lattice site, total angular momentum is conserved.
Therefore, all changes of the spin are accompanied by the appearance of the
angular orbital momentum. This way excited Wannier states with non vanishing
angular orbital momentum can be created. Resonant dipolar coupling of the two
component Bose gas introduces additional degree of control of the system, and
leads to a variety of different stable phases. The phase diagram for small
number of particles is discussed.Comment: 4 pages, 2 figure
Higher Renal Replacement Therapy Dose Delivery Influences on Drug Therapy
Higher doses of renal replacement therapy have profound effects on pharmacotherapy, yet little research has been conducted in this area. High-volume renal replacement therapies influence both the pharmacokinetic and the pharmacodynamic profiles of all drugs administered to these critically ill patients. Intermittent high-dose “hybrid” hemodialysis therapies remove drugs to a much different degree than standard thrice-weekly hemodialysis, yet pharmacokinetic studies have not been performed in patients receiving these therapies. High-volume continuous renal replacement therapies offer dosing challenges not seen with standard low-dose therapies. This article describes the pharmacokinetic and pharmacodynamic issues presented by high-volume renal replacement therapies. Given the importance that pharmacotherapy has on optimal patient outcomes, a better understanding of the influence that high-volume renal replacement therapy has on drugs is essential if these high volume therapies are to be used successfully in the intensive care unit.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75000/1/j.1525-1594.2003.07283.x.pd
Pharmacokinetics of Cefuroxime are not Significantly Altered by Cardiopulmonary Bypass in Children
Poster presented at: SPA/AAP PEDIATRIC ANESTHESIOLOGY 2010 - Winter Meeting; April 2010; San Antonio, TX
The Analyzing Power for p-p Scattering at 180 MeV
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Gentamicin pharmacokinetics and pharmacodynamics during short-daily hemodialysis
BACKGROUND/AIMS: Gentamicin pharmacokinetics have not been described in patients undergoing short-daily hemodialysis (SDHD). The aim of this study is to describe gentamicin pharmacokinetics and dialytic clearance (Cl(dial)) in SDHD patients and simulate gentamicin exposure after six dosing regimens to help guide future dosing.
METHODS: Six anuric patients undergoing SDHD were enrolled. Patients received intravenous infusion of 2 mg/kg gentamicin on day 1 after the first HD session followed by HD sessions on days 2, 3, and 4. Blood samples for determination of gentamicin concentrations were serially collected. Gentamicin pharmacokinetic parameters and Cl(dial) and interindividual variability terms (IIV) were estimated using NONMEM VII. Influence of patient weight on systemic clearance (Cl(s)) and central volume of distribution (V(c)) and influence of urea removal estimates on Cl(dial) were assessed. The model was used to simulate gentamicin concentrations after six dosing regimens including pre- and postdialysis as well as daily and every-other-day dosing.
RESULTS: A two-compartment model with first-order elimination from central compartment described gentamicin pharmacokinetics. Population estimates for Cl(s) and Cl(dial) were 7.6 and 134 ml/min, respectively. Patient weight was statistically significantly associated with Cl(s) and V(c). Predialysis every-other-day regimens were as effective (C(max) ≥8 mg/l and AUC(48 h) ≥140 mg·h/l) and less toxic (C(min) <2 mg/l and AUC(48 h) <240 mg·h/l) than postdialysis regimens.
CONCLUSIONS: Estimated gentamicin Cl(dial) is higher than previous estimates with thrice-weekly regimens. Predialysis every-other-day dosing may be recommended during SDHD
O-Band Subwavelength Grating Filters in a Monolithic Photonics Technology
The data communications industry has begun transitioning from electrical to
optical interconnects in datacenters in order to overcome performance
bottlenecks and meet consumer needs. To mitigate the costs associated with this
change and achieve performance for 5G and beyond, it is crucial to explore
advanced photonic devices that can enable high-bandwidth interconnects via
wavelength-division multiplexing (WDM) in photonic integrated circuits.
Subwavelength grating (SWG) filters have shown great promise for WDM
applications. However, the small feature sizes necessary to implement these
structures have prohibited them from penetrating into industrial applications.
To explore the manufacturability and performance of SWG filters in an
industrial setting, we fabricate and characterize O-band subwavelength grating
filters using the monolithic photonics technology at GLOBALFOUNDRIES (GF). We
demonstrate a low drop channel loss of -1.2 dB with a flat-top response, a high
extinction ratio of -30 dB, a 3 dB channel width of 5 nm and single-source
thermal tunability without shape distortion. This filter structure was designed
using elements from the product design kit provided by GF and functions in a
compact footprint of 0.002 mm2 with a minimum feature size of 150 nm.Comment: 4 pages, 3 figure
Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in Critically I ll Patients Receiving Continuous Venovenous Hemodialysis and/or Extracorporeal Membrane Oxygenation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94511/1/phar1151.pd
Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
Objectives
We tested the hypothesis that oral progesterone administration attenuates drug-induced QT interval lengthening.
Background
Evidence from preclinical and human investigations suggests that higher serum progesterone concentrations may be protective against drug-induced QT interval lengthening.
Methods
In this prospective, double-blind, crossover study, 19 healthy female volunteers (21-40 years) were randomized to receive progesterone 400 mg or matching placebo orally once daily for 7 days timed to the menses phase of the menstrual cycle (between-phase washout period = 49 days). On day 7, ibutilide 0.003 mg/kg was infused over 10 minutes, after which QT intervals were recorded and blood samples collected for 12 hours. Prior to the treatment phases, subjects underwent ECG monitoring for 12 hours to calculate individualized heart rate-corrected QT intervals (QTcI).
Results
Fifteen subjects completed all study phases. Maximum serum ibutilide concentrations in the progesterone and placebo phases were similar (1247±770 vs 1172±709 pg/mL, p=0.43). Serum progesterone concentrations were higher during the progesterone phase (16.2±11.0 vs 1.2±1.0 ng/mL, p<0.0001), while serum estradiol concentrations in the two phases were similar (89.3±62.8 vs 71.8±31.7 pg/mL, p=0.36). Pre-ibutilide lead II QTcI was significantly lower in the progesterone phase (412±15 vs 419±14 ms, p=0.04). Maximum ibutilide-associated QTcI (443±17 vs 458±19 ms, p=0.003), maximum percent increase in QTcI from pretreatment value (7.5±2.4 vs 9.3±3.4%, p=0.02) and area under the effect (QTcI) curve during the first hour post-ibutilide (497±13 vs 510±16 ms-hr, p=0.002) were lower during the progesterone phase. Progesterone-associated adverse effects included fatigue/malaise and vertigo.
Conclusions
Oral progesterone administration attenuates drug-induced QTcI lengthening
IUCF High Intensity Polarized Ion Source
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
- …